Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Idiopathic generalized myokymia

P W Jamieson1, M B Katirji

  • 1Department of Neurology, University of Kansas Medical Center, Kansas City 66160-7314.

Muscle & Nerve
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automating clinical practice guidelines: a corporate-academic partnership.

Clinical laboratory management review : official publication of the Clinical Laboratory Management Association·1996
Same author

Mononeuritis multiplex. A harbinger of acute leukemia in relapse.

Archives of neurology·1994
Same author

Lambert-Eaton myasthenic syndrome associated with an ameloblastoma of the tibia.

Muscle & nerve·1993
Same author

Intravenous methocarbamol in the treatment of stiff-man syndrome.

Muscle & nerve·1993
Same author

Extraocular muscles are spared in advanced Duchenne dystrophy.

Annals of neurology·1992
Same author

Neurology research: a journal survey, 1980-1990.

Annals of neurology·1992
Same journal

Join AANEM.

Muscle & nerve·2026
Same journal

Targeted Muscle Reinnervation for Management and Prevention of Symptomatic Neuroma.

Muscle & nerve·2026
Same journal

AANEM News & Insights.

Muscle & nerve·2026
Same journal

Fat-Fraction Quantification Using Three-Point Dixon Technique in Duchenne Muscular Dystrophy and Its Correlation With Clinical Progression and Genotypic Characteristics: A Single Centre One-Year Prospective Study.

Muscle & nerve·2026
Same journal

Characterizing Combined Central and Peripheral Demyelination-Insights From a Multimodal Comparison With Chronic Inflammatory Demyelinating Polyneuropathy and Multiple Sclerosis.

Muscle & nerve·2026
Same journal

Electrical Modalities in the Rehabilitation of Peripheral Nerve Injuries: State of the Literature and Current Clinical Applications.

Muscle & nerve·2026
See all related articles

Idiopathic generalized myokymia (IGM) is a rare neuromuscular disorder characterized by muscle stiffness and twitching. Phenytoin and carbamazepine show effectiveness in treating this condition.

Area of Science:

  • Neurology
  • Clinical Electrophysiology

Background:

  • Idiopathic generalized myokymia (IGM) is a rare and poorly understood neuromuscular syndrome.
  • This study analyzes 75 reported cases to elucidate IGM's characteristics and presentation.

Observation:

  • IGM affects males and females equally, with a mean onset age of 29 years.
  • Common symptoms include stiffness (60%), cramps (12%), weakness (12%), and muscle twitching (4%).
  • Neurological findings reveal hyporeflexia (70%), weakness (45%), grip myotonia (39%), and calf hypertrophy (16%).

Findings:

  • Generalized clinical myokymia is present in 92% of patients.
  • Electromyography (EMG) documented spontaneous continuous motor unit activity or electrical myokymia in all cases.
  • Electrical myokymia, observed in 66%, featured irregular grouped discharges at 2-300 Hz.

Related Experiment Videos

Implications:

  • IGM presents a wide spectrum of symptoms and severity.
  • Consider IGM in patients with stiffness, cramps, or muscle twitching.
  • EMG is crucial for diagnosing IGM.