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Paraneoplastic pseudo-obstruction, mononeuropathy multiplex, and sensory neuronopathy
B C Liang1, J W Albers, A A Sima
1Department of Neurology, University of Michigan, Medical Center, Ann Arbor 48109-0316.
Muscle & Nerve
|January 1, 1994
Summary
A rare paraneoplastic neuropathy, linked to small cell lung cancer, caused severe gastrointestinal issues. Early cancer treatment may halt nerve damage progression.
Area of Science:
- Neurology
- Oncology
Background:
- Paraneoplastic neuropathies are rare neurological disorders.
- Small cell lung carcinoma is a common cause of paraneoplastic syndromes.
Observation:
- A patient presented with mononeuropathy multiplex, sensory neuronopathy, and diffuse intestinal pseudo-obstruction.
- Gastrointestinal symptoms included gastroparesis and impaired small and large bowel motility.
Findings:
- The patient was diagnosed with small cell carcinoma of the lung.
- Antibody studies confirmed paraneoplastic neuropathy with antineuronal nuclear antibodies.
Implications:
- Early identification of paraneoplastic neuropathy is crucial.
- Prompt treatment of the underlying small cell lung cancer may halt neurological disorder progression.