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Comparison of current alkylating agents with a homo-aza-steroidal ester for antineoplastic activity
P Catsoulacos1, A Papageorgiou, E Margarity
1Department of Pharmacy, School of Health and Sciences, University of Patras, Greece.
Oncology
|January 1, 1994
Abstract:
The modified steroidal alkylating agent, 17 beta-hydroxy-3-aza-A-homo-4 alpha-androsten-4-one-p-bis(2-chloroethyl)aminophenoxyacetate++ + has been tested against L1210 and P388 leukemias, and Lewis lung cancer, on DNA synthesis of EAT, L1210, P388, and BHK cell cultures, and on the induction of sister chromatid exchange. Comparable studies in vivo and in vitro were also done with p-bis(2-chloroethyl)aminophenoxyacetic acid, cyclophosphamide, melphalan, and chlorambucil.