Related Experiment Video

Updated: Oct 9, 2026

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

Oral immunoglobulins for treatment of acute rotaviral gastroenteritis

A Guarino1, R B Canani, S Russo

  • 1Department of Pediatrics, University Federico II, Naples, Italy.

Pediatrics
|January 1, 1994
PubMed

Insights

Oral immunoglobulin significantly speeds recovery for children with rotavirus gastroenteritis. This treatment reduces diarrhea duration and hospital stays, offering a faster return to health.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Immunology

Background:

  • Preliminary evidence suggests oral human serum immunoglobulin has an antirotavirus effect.
  • Rotavirus acute gastroenteritis is a common cause of illness in children, necessitating effective treatments.

Purpose of the Study:

  • To evaluate the efficacy of oral immunoglobulin treatment in children with rotavirus acute gastroenteritis.

Main Methods:

  • A prospective, double-blind, placebo-controlled study involving 98 children with acute gastroenteritis.
  • Children received either oral human serum immunoglobulin (300 mg/kg) or a placebo.
  • Efficacy was assessed by clinical condition, stool characteristics, diarrhea duration, viral excretion, and hospital stay. Antirotaviral activity of the immunoglobulin was confirmed via neutralization assay.

Main Results:

  • In children with rotaviral gastroenteritis (71/98), the immunoglobulin group showed significantly faster clinical improvement and stool pattern normalization compared to the placebo group.
  • Mean diarrhea duration was reduced from 131 hours (placebo) to 76 hours (immunoglobulin) (P < .01).
  • Viral excretion and hospital stay were also significantly shorter in the immunoglobulin group (P < .01).

Conclusions:

  • Oral immunoglobulin administration is associated with accelerated recovery from rotavirus acute gastroenteritis in children.
  • This treatment should be considered for children hospitalized with this condition.
  • The study confirms the presence of neutralizing antibodies against rotavirus in the immunoglobulin preparation.
Abstract

More Related Videos

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Cationic Nanoemulsion-Encapsulated Retinoic Acid as an Adjuvant to Promote OVA&#45;Specific Systemic and Mucosal Responses06:02

Cationic Nanoemulsion-Encapsulated Retinoic Acid as an Adjuvant to Promote OVA-Specific Systemic and Mucosal Responses

Published on: February 23, 2024

Related Concept Videos

Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...