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Pill-induced esophageal ulcer

I Yap1, R Guan, J Y Kang

  • 1Department of Medicine, National University Hospital, Singapore.

Singapore Medical Journal
|June 1, 1993
PubMed
Summary

Prescribed medications, especially antibiotics, can cause esophageal injury. Symptoms like pain and difficulty swallowing, along with mid-esophageal ulcers, indicate this drug-induced condition.

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Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Pharmacology

Background:

  • Esophageal injury from ingested medications is an underrecognized clinical entity.
  • Certain drugs possess properties that can directly irritate or damage the esophageal mucosa.

Purpose of the Study:

  • To report nine cases of esophageal injury caused by prescribed medications.
  • To identify common clinical presentations, endoscopic findings, and causative agents.

Main Methods:

  • Case series describing nine patients with esophageal injury.
  • Review of clinical history, symptoms, and endoscopic findings.
  • Analysis of implicated medications.

Main Results:

  • Nine patients presented with odynophagia, retrosternal chest pain, and dysphagia.
  • Antibiotics were the most frequent offenders.
  • Endoscopy revealed discrete ulcers predominantly in the mid-esophagus.

Conclusions:

  • Drug-induced esophageal injury should be suspected in patients with acute esophageal symptoms and ulcerations.
  • Discontinuation of the offending drug and symptomatic management lead to uneventful recovery.

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