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Crystal-deficient alveolar soft part sarcoma

J A Tucker1

  • 1Department of Pathology, University of South Alabama, Mobile.

Ultrastructural Pathology
|May 1, 1993
PubMed
Summary
This summary is machine-generated.

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Alveolar soft part sarcoma diagnosis may require careful ultrastructural examination. While large crystals are classically seen, round granules with characteristic substructure are more consistently present and aid in definitive diagnosis.

Area of Science:

  • Oncology
  • Pathology
  • Electron Microscopy

Background:

  • Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma.
  • Classical ultrastructural findings include large, rhomboid to needlelike crystals with a characteristic substructure.

Purpose of the Study:

  • To evaluate the ultrastructural features of ASPS, focusing on the presence and diagnostic utility of crystals and granules.
  • To determine if large crystals are consistently found in ASPS.

Main Methods:

  • Ultrastructural examination (electron microscopy) of four cases of alveolar soft part sarcoma.
  • Detailed analysis of crystalline structures and electron-dense granules within tumor cells.

Main Results:

  • Only two of the four ASPS cases exhibited rare, large crystals.

Related Experiment Videos

  • All four cases showed round, electron-dense granules.
  • In cases lacking large crystals, granules rarely showed elongation with the characteristic ASPS substructure.
  • Previous ultrastructural studies at other institutions failed to identify crystals in two of these cases.

    • Conclusions:

    • Large crystals may be rare or absent in alveolar soft part sarcoma.
    • Electron-dense granules with characteristic periodic substructure are consistently present and crucial for definitive diagnosis.
    • Careful ultrastructural examination is necessary to identify diagnostic features in ASPS.