Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Preparing cytotoxic agents in an isolator

M Favier1, S Hansel, F Bressolle

  • 1Pharmacy Service, CHU G. Doumergue, Nîmes, France.

American Journal of Hospital Pharmacy
|November 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trichophyton mentagrophytes ITS genotype VII infections among men who have sex with men in France: An ongoing phenomenon.

Journal of the European Academy of Dermatology and Venereology : JEADV·2024
Same author

Early Medical Abortion - Education and Training Experiences.

Irish medical journal·2024
Same author

Array of Individual Circular Rydberg Atoms Trapped in Optical Tweezers.

Physical review letters·2023
Same author

From the original SARS-CoV-2 strain to the Omicron variant: Predictors of COVID-19 in ambulatory symptomatic children.

Infectious diseases now·2022
Same author

Factors associated with hospital admission and adverse outcome for COVID-19: Role of social factors and medical care.

Infectious diseases now·2022
Same author

Laser Trapping of Circular Rydberg Atoms.

Physical review letters·2020
Same journal

National health care reform, Part 2: Response to pharmacists.

American journal of hospital pharmacy·1994
Same journal

Validity of originality assessment.

American journal of hospital pharmacy·1994
Same journal

Unit dose dispensing of chromic phosphate P 32 suspension.

American journal of hospital pharmacy·1994
Same journal

Hydralazine injection still available.

American journal of hospital pharmacy·1994
Same journal

Improved extemporaneous formulation of cyclosporine ophthalmic drops.

American journal of hospital pharmacy·1994
Same journal

Paclitaxel diluent and the case of the slippery spike.

American journal of hospital pharmacy·1994
See all related articles

This study details a Class III biological-safety cabinet isolator for preparing cytotoxic drugs in an oncology pharmacy. The design ensures safe handling of hazardous medications through advanced ventilation and sterilization.

Area of Science:

  • Pharmacy Practice
  • Pharmaceutical Technology
  • Occupational Safety

Background:

  • Cytotoxic drugs require specialized handling to protect healthcare workers and patients.
  • Oncology pharmacies face challenges in safely preparing complex sterile admixtures.
  • Existing containment solutions may not offer adequate protection or workflow efficiency.

Purpose of the Study:

  • To describe the design and implementation of a Class III isolator for cytotoxic drug preparation.
  • To evaluate the safety features and operational workflow of the isolator in an oncology satellite pharmacy.
  • To outline maintenance and decontamination procedures for the isolator system.

Main Methods:

  • Detailed description of the Iso Concept Class III isolator, including its positive air pressure, half-suit, and glove system.

Related Experiment Videos

  • Explanation of the ventilation and HEPA filtration system for maintaining a sterile environment.
  • Outline of the sterilization process using peracetic acid and compressed air, and routine maintenance protocols.

    • Main Results:

    • The isolator provides a totally enclosed, ventilated environment for cytotoxic drug preparation.
    • The system incorporates multiple safety features, including HEPA filtration and an air lock with sterilization.
    • Defined procedures for preparation, supervision, labeling, and dose verification were established.

    Conclusions:

    • The described isolator design offers a robust solution for the safe preparation of cytotoxic drugs.
    • Implementation in an oncology satellite pharmacy enhances safety for personnel and product integrity.
    • Regular maintenance and adherence to protocols are crucial for sustained safe operation.