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The degree of blood pressure evaluation and end organ damage with severe hypertension: a case-control study

A M Fournier1, L J Hoenig, J M Sosenko

  • 1Department of Medicine, University of Miami School of Medicine, Florida 33101.

The American Journal of the Medical Sciences
|December 1, 1993
PubMed

Insights

Severe hypertension is linked to end-organ damage, especially with higher blood pressure, prior hypertensive crisis, elevated creatinine, and alcohol use. These factors are crucial for understanding hypertension complications.

Area of Science:

  • Nephrology
  • Cardiology
  • Hypertension Research

Background:

  • Severe hypertension poses a significant risk for developing end-organ damage.
  • Identifying factors associated with end-organ damage is critical for patient management.

Purpose of the Study:

  • To investigate the association between blood pressure levels and end-organ damage in patients with severe hypertension.
  • To compare patients with severe hypertension and acute end-organ damage against those with severe but asymptomatic hypertension.

Main Methods:

  • A case-controlled study comparing 26 patients with end-organ damage and severe hypertension to 25 asymptomatic patients.
  • Utilized Chi-square test and multiple logistic regression analysis for data assessment.

Main Results:

  • Multivariate analysis revealed significant associations between end-organ damage and systolic/diastolic blood pressure elevation, history of hypertensive crisis, serum creatinine, and alcohol use.
  • Univariate analysis did not show a relationship with creatinine or history of hypertensive crisis.

Conclusions:

  • Degree of blood pressure elevation, prior hypertensive crisis, elevated creatinine, and alcohol use are associated with end-organ damage in severe hypertension.
  • These findings highlight key risk factors for hypertensive end-organ damage.

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