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A double-blind, placebo-controlled crossover study of ganglioside GM1 treatment for Alzheimer's disease
C Flicker1, S H Ferris, D Kalkstein
1Department of Psychiatry, New York University Medical Center, NY 10016.
The American Journal of Psychiatry
|January 1, 1994
Abstract:
In a double-blind trial, 12 patients with probable Alzheimer's disease were treated for 6 weeks with placebo and 6 weeks with monosialoganglioside (GM1) (100 mg/day i.m.), which potentiates the actions of nerve growth factor. GM1 failed to produce significant improvement in patients' cognitive test performance, suggesting that this is not a viable approach to the treatment of cognitive deterioration in Alzheimer's disease.