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Related Experiment Videos

Naloxone, meperidine, and shivering

M Kurz1, K G Belani, D I Sessler

  • 1Department of Transfusion Medicine, Waehringer Güertel, Vienna, Austria.

Anesthesiology
|December 1, 1993
PubMed
Summary

Meperidine

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Area of Science:

  • Pharmacology
  • Neuroscience

Background:

  • Meperidine's effectiveness in treating shivering surpasses morphine, suggesting kappa receptor involvement.
  • Butorphanol, a kappa agonist/antagonist, is more effective than fentanyl for shivering, further supporting kappa receptor activity.

Purpose of the Study:

  • To test the hypothesis that meperidine's antishivering activity is mediated by kappa receptors.
  • To evaluate the impact of naloxone, a mu and kappa receptor antagonist, on meperidine's antishivering effects.

Main Methods:

  • Shivering was induced in 12 volunteers using cold fluid infusion.
  • Volunteers received either placebo, low-dose naloxone (mu-receptor blockade), or high-dose naloxone (mu and kappa receptor blockade).
  • Meperidine was administered intravenously, and shivering intensity (oxygen consumption) and opioid effects (pupillary response) were measured.

Main Results:

  • Meperidine alone reduced oxygen consumption and caused pupillary constriction.
  • Low-dose naloxone minimally impaired meperidine's antishivering effect and pupillary response.
  • High-dose naloxone largely prevented meperidine's antishivering effect and pupillary response.

Conclusions:

  • Meperidine's antishivering property is not solely mediated by mu-receptors.
  • Kappa receptor stimulation is a likely explanation for a significant portion of meperidine's antishivering action.
  • These findings highlight the role of kappa receptors in meperidine's therapeutic effects beyond mu-receptor agonism.

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