Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in ventricular geometry early after Fontan operation

A J Chin1, W H Franklin, B A Andrews

  • 1Division of Cardiology, Children's Hospital of Philadelphia, Pennsylvania 19104.

The Annals of Thoracic Surgery
|December 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Analyzing redox balance in a synthetic yeast platform to improve utilization of brown macroalgae as feedstock.

Metabolic engineering communications·2021
Same author

Bone morphogenetic protein-4 expression characterizes inductive boundaries in organs of developing zebrafish.

Development genes and evolution·2016
Same author

Characterization of Ferroplasma acidiphilum growing in pure and mixed culture with Leptospirillum ferriphilum.

Biotechnology progress·2016
Same author

Genome-scale reconstruction of Salinispora tropica CNB-440 metabolism to study strain-specific adaptation.

Antonie van Leeuwenhoek·2015
Same author

Stoichiometric model and flux balance analysis for a mixed culture of Leptospirillum ferriphilum and Ferroplasma acidiphilum.

Biotechnology progress·2014
Same author

Amniocentesis.

Journal of genetic counseling·2013

Ventricular geometric alterations after Fontan operation can impair diastolic function. These changes are more pronounced following the Fontan procedure compared to the hemi-Fontan, especially in infants and affecting both ventricles.

Area of Science:

  • Pediatric Cardiology
  • Congenital Heart Disease
  • Cardiac Surgery

Background:

  • Fontan operation is a palliative procedure for complex congenital heart defects.
  • Ventricular volume overload is a common issue post-Fontan operation.
  • Geometric alterations can negatively impact diastolic function.

Purpose of the Study:

  • To compare geometric alterations after Fontan vs. hemi-Fontan operations.
  • To assess the impact of age (infants vs. children) on these alterations.
  • To evaluate differences in geometric changes between morphologic right and left ventricles.

Main Methods:

  • Retrospective study of 22 patients with hypoplastic left heart syndrome or functionally single left ventricle.
  • Analysis of ventricular volumes and wall thickness before and after surgery.

Related Experiment Videos

  • Comparison between Fontan and hemi-Fontan procedures, and between age groups.

    • Main Results:

    • Significant reductions in end-diastolic volumes for both right (52%) and left (40%) ventricles post-Fontan.
    • Increased ventricular wall thickness in both ventricles.
    • More severe alterations after Fontan than hemi-Fontan, and in infants compared to children.
    • Similar magnitude of alterations in morphologic right and left ventricles.

    Conclusions:

    • Fontan operation leads to significant ventricular geometric alterations impacting diastolic performance.
    • Early surgical stage (Fontan vs. hemi-Fontan) and patient age influence the severity of these changes.
    • Both ventricles undergo substantial geometric remodeling, with similar impact on morphologic right and left ventricles.