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Related Experiment Videos

Hemofiltration modifies complement activation after extracorporeal circulation in infants

S Andreasson1, S Göthberg, H Berggren

  • 1Department of Pediatric Anesthesia, East Hospital, Gothenburg, Sweden.

The Annals of Thoracic Surgery
|December 1, 1993
PubMed
Summary
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Hemofiltration effectively reduced elevated complement factors, such as C3a and C5a, in infants after cardiopulmonary bypass. However, it did not impact the fibrinolytic system.

Area of Science:

  • Pediatric critical care medicine
  • Cardiovascular surgery
  • Renal replacement therapy

Background:

  • Cardiopulmonary bypass (CPB) can activate the complement system.
  • Elevated complement activation is associated with adverse outcomes in infants post-CPB.
  • Fibrinolytic system activation also occurs during CPB.

Purpose of the Study:

  • To evaluate the efficacy of hemofiltration in reducing complement and fibrinolytic system activation post-CPB in infants.
  • To determine if hemofiltration can remove activated complement factors from circulation.

Main Methods:

  • Nine infants undergoing hemofiltration immediately after CPB were studied.
  • Plasma levels of complement factors (C3a, C5a, terminal complement complexes) and fibrinolytic factors were measured.

Related Experiment Videos

  • Ultrafiltrate was analyzed for filtered complement and fibrinolytic components.

    • Main Results:

    • Plasma levels of C3a, C5a, and terminal complement complexes significantly increased during CPB.
    • Hemofiltration reduced plasma levels of C3a and C5a in 8 of 9 infants.
    • Filtered C3a and C5a were detected in the ultrafiltrate.
    • Hemofiltration did not alter the activation of the fibrinolytic system, and fibrinolytic factors were not filtered.

    Conclusions:

    • Hemofiltration is effective in reducing elevated plasma concentrations of complement factors after CPB in infants.
    • Hemofiltration may mitigate complement system activation in this vulnerable population.
    • The fibrinolytic system's activation appears unaffected by hemofiltration post-CPB.