Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Torsades de pointes]

L Guize¹, M C Iliou, G Bayet

¹Département de cardiologie, hôpital Broussais, Paris.

Archives Des Maladies Du Coeur Et Des Vaisseaux

|May 1, 1993

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Systematic Evaluation of Benchmark G4 Probes and G4 Clinical Drugs using three Biophysical Methods: A Guideline to Evaluate Rapidly G4-Binding Affinity.

Chembiochem : a European journal of chemical biology·2024

Same author

EU-CaRE study: Could exercise-based cardiac telerehabilitation also be cost-effective in elderly?

International journal of cardiology·2021

Same author

Constrained G4 structures unveil topology specificity of known and new G4 binding proteins.

Scientific reports·2021

Same author

[Fighting against unexplained sudden death].

Annales de cardiologie et d'angeiologie·2021

Same author

[Sinus node dysfunction associated with cardiac sarcoidosis: A case report].

La Revue de medecine interne·2021

Same author

Surface plasmon resonance study of the interaction of N-methyl mesoporphyrin IX with G-quadruplex DNA.

Physical chemistry chemical physics : PCCP·2020

Same journal

Radiokymographic study of the kinetics of the middle arc and the hils in the normal subject.

Archives des maladies du coeur et des vaisseaux·2010

Same journal

A medication for angina pectoris and pre-fibrillatory conditions; 1262 F; six years of clinical experience; action mechanism.

Archives des maladies du coeur et des vaisseaux·2010

Same journal

Circulatory changes following the injection of hypertonic saline solutions; application to the study of angina pectoris.

Archives des maladies du coeur et des vaisseaux·2010

Same journal

Alterations in coronary circulation during aortic insufficiency in young subjects.

Archives des maladies du coeur et des vaisseaux·2010

Same journal

Cardio-esophageal auscultation.

Archives des maladies du coeur et des vaisseaux·2010

Same journal

Hypertensive accidents following the injection of acetylcholine.

Archives des maladies du coeur et des vaisseaux·2010

See all related articles

Torsades de pointes are rapid heart rhythms characterized by specific ECG patterns, potentially leading to syncope or sudden death. Management involves magnesium, pacing, and addressing underlying repolarization abnormalities.

Area of Science:

Cardiology
Electrophysiology

Context:

Torsades de pointes (TdP) are a specific type of polymorphic ventricular tachycardia.
These arrhythmias are associated with prolonged QT intervals and abnormal ventricular repolarization.

Purpose:

To define and characterize Torsades de pointes.
To explore the underlying electrophysiological mechanisms and identify causes.
To outline current and potential therapeutic strategies.

Summary:

TdP presents as rapid, polymorphic ventricular tachycardia on ECG, often self-terminating but can cause syncope or sudden death.
Risk factors include congenital syndromes or acquired conditions like bradycardia, certain drugs, and electrolyte imbalances (potassium, magnesium).
Mechanisms involve reentry and triggered activity, with genetic factors influencing ion channels and receptors.

Related Experiment Videos

Impact:

Understanding TdP mechanisms aids in risk stratification and personalized treatment.
Effective management can prevent life-threatening events and improve patient outcomes.
This knowledge supports the development of novel therapeutic interventions for refractory cases.