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Synthesis of some 1,4,5,6,7,8-hexahydroquinoline derivatives and their calcium antagonistic activity
1Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara, Turkey.
Arzneimittel-Forschung
|October 1, 1993
Abstract:
Twenty-seven new 2-methyl-3-acetyl-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives have been prepared. Their structures were confirmed by UV, IR, 1H-NMR and elementary analysis. The calcium antagonistic activity of these compounds was tested in K(+)-depolarized taenia coli precontracted with 1 mmol/l Ca+2.