Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute circulatory support

M J Barnard1, S P Linter

  • 1Harefield Hospital, Middlesex.

BMJ (Clinical Research Ed.)
|July 3, 1993
PubMed
Summary
This summary is machine-generated.

Optimizing cardiac output with drugs requires balancing oxygen delivery and demand. This review covers drug strategies and mechanical assist devices for managing impaired cardiac function and ischemia.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enzymatic synthesis of sorbitan esters using a low-boiling-point azeotrope as a reaction solvent.

Biotechnology and bioengineering·1997
Same author

Delayed excitatory reaction following interaction of cocaine and monoamine oxidase inhibitor (phenelzine).

British journal of anaesthesia·1991
Same author

Depth of extradural space and dural puncture.

Anaesthesia·1991
Same author

Comparison of albumin excretion rate obtained with different times of collection.

Diabetes care·1990
Same author

Anesthesia and mental illness.

International journal of psychiatry in medicine·1990
Same author

Failure of extradural blockade in obstetrics. A new hypothesis.

British journal of anaesthesia·1988
Same journal

Robotic versus Open Pancreatoduodenectomy (PORTAL): multicentre, single masked, phase 3, non-inferiority randomised controlled trial.

BMJ (Clinical research ed.)·2026
Same journal

Venous thromboembolism after mechanical restraint in psychiatric hospitals: population based cohort and self-controlled case series study.

BMJ (Clinical research ed.)·2026
See all related articles

Area of Science:

  • Cardiology
  • Pharmacology
  • Critical Care Medicine

Background:

  • Drugs increasing cardiac output can raise myocardial oxygen demand, critical in impaired cardiac function or ischemia.
  • Effective polypharmacy for cardiovascular improvement necessitates understanding drug pharmacodynamics and interactions.
  • Tailoring treatments to individual patients is crucial for managing complex cardiovascular conditions.

Purpose of the Study:

  • To review pharmacologic agents that increase cardiac output and their impact on myocardial oxygen demand.
  • To discuss the use of inotropes, vasodilators, and vasopressors in cardiovascular management.
  • To explore mechanical assist devices as alternatives when pharmacologic interventions fail.

Main Methods:

  • Review of existing literature on cardiovascular drugs and mechanical assist devices.

Related Experiment Videos

  • Analysis of pharmacodynamic properties and drug interactions relevant to cardiac output management.
  • Discussion of clinical scenarios necessitating specific therapeutic approaches.

    • Main Results:

    • Many drugs enhance cardiac output but may increase myocardial oxygen demand.
    • Combinations of inotropes and vasodilators can minimize cardiac workload.
    • Vasopressors are vital for urgently restoring perfusion pressure.

    Conclusions:

    • Careful selection and combination of cardiovascular drugs are essential for improving tissue oxygen delivery while managing myocardial oxygen demand.
    • Mechanical assist devices offer crucial support when pharmacologic therapies are insufficient.
    • Individualized treatment strategies are paramount in critical cardiovascular care.