[Application of beta-cyclodextrin inclusion complex in liushen pills]

Area of Science:

• Traditional Chinese Medicine
• Pharmaceutical Sciences
• Drug Delivery Systems

Background:

• Liushen Pills are a widely used traditional Chinese medicine.
• Improving the stability and efficacy of traditional medicines is crucial.
• Beta-cyclodextrin (beta-CD) inclusion complex technology offers potential for drug formulation enhancement.

Purpose of the Study:

• To compare the quality, stability, and pharmacological effects of Liushen Pills prepared with beta-CD inclusion complex versus conventional methods.
• To evaluate the impact of beta-CD complexation on Liushen Pills' properties.

Main Methods:

• Comparative quality inspection.
• Stability testing under various conditions.
• Pharmacological experiments assessing irritative effects.
• Dissolution testing to determine drug release profiles.

Main Results:

• Liushen Pills prepared with beta-CD inclusion complex (01 Liushen Pills) exhibited enhanced quality attributes.
• The beta-CD complex formulation showed improved stability.
• Pharmacological experiments indicated superior performance of 01 Liushen Pills.
• Dissolution tests revealed favorable drug release characteristics for the beta-CD complex.

Conclusions:

• Beta-cyclodextrin inclusion complexation significantly improves the quality, stability, and pharmacological efficacy of Liushen Pills.
• This formulation strategy presents a promising approach for enhancing traditional Chinese medicine preparations.