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A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
Published on: November 9, 2017
[Tick-borne meningopolyneuritis (Garin-Bujadoux, Bannwarth)]
Abstract:
The meningopolyneuritis first described in 1922 by Garin and Bujadoux develops after a tick bite. At the site of the bite in some of the cases, erythema chronicum migrans develops first. Severe pains follow in this area which may spread to other parts of the body. Then peripheral paralysis appears with asymmetrical distribution. The motor cerebral nerves, especially the facial nerve, are also frequently affected. Mild sensitivity disorders occur with no systematic arrangement. There is a lymphocyte pleocytosis of 100-2600/3 mm3 and an increase in protein of varying intensity, meningeal symptoms usually being absent. The disease persists for 3-5 months. Apart from rare residual, the prognosis is favorable.
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