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Related Experiment Videos

A pumping intravascular artificial lung with active mixing

A J Makarewicz1, L F Mockros, R W Anderson

  • 1Department of Biomedical Engineering, Northwestern University, Evanston, Illinois.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|July 1, 1993
PubMed
Summary

This study presents a novel artificial lung design that enhances gas transfer efficiency and provides its own pumping action. Rotating the device significantly boosts oxygen and carbon dioxide exchange rates.

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Devices
  • Respiratory Support

Background:

  • Artificial lungs (extracorporeal gas exchangers) are crucial for respiratory support.
  • Current devices face challenges in balancing gas transfer efficiency and pressure loss.
  • Effective oxygenation and carbon dioxide removal are primary goals for artificial lung technology.

Purpose of the Study:

  • To develop a novel artificial lung with integrated pumping action.
  • To enhance gas transfer efficiency through device rotation.
  • To investigate the potential of a screw-like configuration for blood flow and gas exchange.

Main Methods:

  • Design and prototyping of a rotating artificial lung with microporous hollow fibers.
  • Cross-flow configuration of hollow fibers arranged in a screw-like manner.

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  • In vitro testing using water and blood to evaluate gas transfer and pumping performance.

    • Main Results:

    • Rotation significantly increased gas transfer rates, up to sixfold in water tests.
    • The device demonstrated moderate blood pumping capability against a zero pressure head.
    • The screw-like configuration facilitated blood movement, simulating veno-venous bypass.

    Conclusions:

    • The rotating artificial lung design shows promise for improved efficiency and reduced pressure loss.
    • Integrated pumping action could simplify extracorporeal circuits.
    • Further development is warranted to optimize performance for clinical applications.