Related Experiment Videos
Development of an expandable intra-aortic prosthesis for experimental aortic dissection
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|July 1, 1993
Summary
Researchers developed a novel intra-aortic (IA) graft for treating Stanford type B aortic dissection. This self-expandable graft successfully closed entry sites in animal models, offering a minimally invasive treatment option.
Area of Science:
- Vascular Surgery
- Biomedical Engineering
- Interventional Cardiology
Background:
- Stanford type B aortic dissection requires effective treatment to prevent complications.
- Transcatheter approaches offer less invasive alternatives to open surgery.
- A need exists for innovative devices to facilitate transcatheter aortic repair.
Purpose of the Study:
- To develop and evaluate a novel self-expandable intra-aortic (IA) graft for transcatheter entry obliteration in Stanford type B aortic dissection.
Main Methods:
- A self-expandable IA graft was designed, comprising a microporous polyurethane graft and a metallic stent.
- The IA graft was delivered via a catheter sheath through the femoral artery.
- Experimental aortic dissections were created in mongrel dogs, and the IA graft was implanted at the entry site.
Main Results:
- Successful implantation and expansion of the IA graft were achieved in all animal subjects.
- Aortography confirmed complete closure of all entry sites within 30 minutes post-implantation.
- The device demonstrated feasibility for transcatheter repair of aortic dissection.
Conclusions:
- The newly devised IA graft is a promising, minimally invasive device for treating Stanford type B aortic dissection.
- This technology offers potential for improved patient outcomes in aortic dissection management.