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Methodologies for measuring carcinogen adducts in humans

P T Strickland1, M N Routledge, A Dipple

  • 1Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
|November 1, 1993
PubMed
Summary

Human biomonitoring has advanced, establishing feasibility for biomarker testing. Future research requires improved carcinogen adduct assays and novel markers for precise cancer risk assessment.

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Area of Science:

  • Environmental health
  • Molecular epidemiology
  • Biomarker research

Background:

  • Human biomonitoring studies have progressed, though initial optimistic goals are not fully met.
  • Feasibility of biomonitoring is established, highlighting the need for biomarker validation before field application.

Purpose of the Study:

  • To review advances in human biomonitoring for carcinogen exposure.
  • To identify future research needs for improving cancer epidemiology through molecular approaches.

Main Methods:

  • Review of existing human biomonitoring studies and biomarker validation.
  • Discussion of advancements in assay reproducibility and specificity for DNA adducts.
  • Exploration of hybrid methodologies and novel marker development.

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Main Results:

  • Biomonitoring feasibility is confirmed through various studies.
  • Preliminary biomarker testing and transitional studies are crucial for field application.
  • Improvements in DNA adduct assay specificity and reproducibility are necessary.

Conclusions:

  • Continued advancements in assay technology and basic carcinogenesis research are vital.
  • Development of new assays for metabolic phenotypes/genotypes will enhance susceptibility estimates.
  • Molecular approaches, enriched by improved assays, will significantly contribute to future cancer epidemiology.