Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypertension in the elderly

L H Lindholm1, T Ekbom

  • 1Health Sciences Centre, Lund University, Dalby, Sweden.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|November 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lowering Albuminuria-Does It Lower the Cardiovascular Risk?: Reduction in Albuminuria Translates to Reduction in Cardiovascular Events in Hypertensive Patients: Losartan Intervention for Endpoint Reduction in Hypertension Study. Hypertension 45: 198-202, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

Reducing Microalbuminuria-Does It Lower Cardiovascular Risk?: Reduction in Albuminuria Translates to Reduction in Cardiovascular Events in Hypertensive Patients: Losartan Intervention for Endpoint Reduction in Hypertension Study. Hypertension 45: 198-202, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

In-treatment HDL cholesterol levels and development of new diabetes mellitus in hypertensive patients: the LIFE Study.

Diabetic medicine : a journal of the British Diabetic Association·2013
Same author

International Society of Hypertension Low and Middle Income Countries Committee: Review of the goals of the Committee and of 5 years of ISH activities in low and middle income countries.

Journal of hypertension·2010
Same author

Reduction in albuminuria translates to reduction in cardiovascular events in hypertensive patients with left ventricular hypertrophy and diabetes.

Journal of nephrology·2008
Same author

The effect of losartan compared with atenolol on the incidence of revascularization in patients with hypertension and electrocardiographic left ventricular hypertrophy. The LIFE study.

Journal of human hypertension·2006

Treating high blood pressure in elderly patients aged 70 and above significantly reduces cardiovascular disease (CVD) and stroke. Blood pressure lowering therapy is recommended for hypertensives up to age 80, considering comorbidities.

Area of Science:

  • Gerontology
  • Cardiology
  • Clinical Pharmacology

Background:

  • Cardiovascular disease (CVD) risk associated with hypertension is well-established in younger elderly (<70-75).
  • Early studies suggested but did not confirm CVD risk reduction from treating hypertension in the elderly.
  • The risk-benefit profile of hypertension treatment in older individuals requires clarification.

Purpose of the Study:

  • To evaluate the efficacy and safety of antihypertensive drug treatment in elderly patients (aged 70 and above).
  • To determine the impact of blood pressure lowering therapy on cardiovascular morbidity and mortality in the elderly.

Main Methods:

  • Review of major clinical trials including the European Working Party on High Blood Pressure in the Elderly (EWPHE), The Randomised Trial of the Treatment of Hypertension in Elderly Patients in Primary Care (HEP), Systolic Hypertension in the Elderly Program (SHEP), Swedish Trial in Old Patients with Hypertension (STOP), and Medical Research Council (MRC) trials.

Related Experiment Videos

  • Analysis of data on drug tolerability (beta-blockers and diuretics) and clinical outcomes.

    • Main Results:

    • Major trials confirmed the benefits of treating hypertension in the elderly up to age 70-74.
    • Subsequent trials including older patients and those with isolated systolic hypertension corroborated these findings.
    • Drug treatment with beta-blockers and diuretics demonstrated significant reductions in cardiovascular events, particularly stroke, without significant tolerability issues.

    Conclusions:

    • Antihypertensive drug treatment, specifically with beta-blockers and diuretics, offers significant and clinically relevant reductions in cardiovascular morbidity and mortality in hypertensive individuals aged 70 and older.
    • Blood pressure lowering therapy should be considered for elderly hypertensives up to age 80.
    • Treatment plans must be individualized, accounting for potential comorbidities common in elderly patients.