Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Withdrawal from ethanol: simple quantitative behavioral tests for its evaluation

L A Pohorecky

    Psychopharmacology
    |November 10, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Social housing influences the composition of volatile compounds in the preputial glands of male rats.

    Hormones and behavior·2008
    Same author

    Differing effects of acute and chronic stressors on plasma osteocalcin and leptin in rats.

    Stress (Amsterdam, Netherlands)·2007
    Same author

    Bidirectional changes in ethanol consumption in rats with site-specific antisense down-regulation of 5-hydroxytryptamine2A receptors in brain.

    The Journal of pharmacology and experimental therapeutics·2001
    Same author

    Individual differences in pavlovian autoshaping of lever pressing in rats predict stress-induced corticosterone release and mesolimbic levels of monoamines.

    Pharmacology, biochemistry, and behavior·2000
    Same author

    Testing the genetics of behavior in mice.

    Science (New York, N.Y.)·1999
    Same author

    Effect of chronic social stress on delta-opioid receptor function in the rat.

    The Journal of pharmacology and experimental therapeutics·1999
    Same journal

    Sotagliflozin pretreatment attenuates acute LPS-induced depression-like behavioral abnormalities and modulates the gut microbiota-immune-brain axis.

    Psychopharmacology·2026
    Same journal

    GlyT1 inhibition enhances working memory in the mouse TUNL task and normalizes NMDA antagonist-induced network activity.

    Psychopharmacology·2026
    Same journal

    Effects of repeated treatment with opioids that vary in mu opioid receptor efficacy on pain-depressed locomotor behavior in mice.

    Psychopharmacology·2026
    Same journal

    Cannabidiol in the anterior insular cortex attenuates chronic neuropathic pain and comorbid anxiety- and depression-like behaviors: involvement of CB<sub>1</sub> and 5-HT<sub>1A</sub> receptor signaling.

    Psychopharmacology·2026
    Same journal

    Fentanyl decreases arterial blood oxygen saturation more than furanylfentanyl in mice due to increased apnea.

    Psychopharmacology·2026
    Same journal

    Suicide attempt risk among patients receiving methylphenidate: a retrospective cohort study.

    Psychopharmacology·2026
    See all related articles

    Ethanol withdrawal in rats significantly reduced locomotor activity, head-poke, and rearing behaviors for 3-5 days. These quantifiable behavioral changes can assess the severity of ethanol withdrawal syndrome.

    Area of Science:

    • Neuroscience
    • Behavioral Science
    • Pharmacology

    Background:

    • Chronic ethanol consumption leads to physical dependence.
    • Abrupt cessation of ethanol triggers withdrawal symptoms.
    • Understanding ethanol withdrawal is crucial for addiction research.

    Purpose of the Study:

    • To evaluate behavioral changes during ethanol withdrawal in rats.
    • To identify reliable indicators of withdrawal severity.
    • To establish a preclinical model for studying ethanol dependence.

    Main Methods:

    • Rats were maintained on an ethanol-containing liquid diet for 6 weeks.
    • Behavioral assessments were conducted during ethanol withdrawal.
    • Locomotor activity, head-poke, and rearing were quantified.

    Related Experiment Videos

    Main Results:

    • Ethanol-withdrawn rats showed significantly decreased locomotor activity.
    • Reduced head-poke and rearing behaviors were observed.
    • Behavioral disturbances persisted for 3-5 days post-withdrawal.

    Conclusions:

    • Decreased locomotor activity, head-poke, and rearing are sensitive measures of ethanol withdrawal.
    • These behaviors provide a quantitative method for assessing withdrawal severity in rats.
    • The findings support the use of these behaviors in preclinical ethanol dependence research.