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Impact of omeprazole on the plasma clearance of methotrexate
1Department of Medicine, Stanford University Medical Center, CA 94305.
Cancer Chemotherapy and Pharmacology
|January 1, 1993
Abstract:
Omeprazole inhibits the gastric hydrogen pump and is an effective treatment for peptic ulcers. Methotrexate is a chemotherapeutic agent that inhibits dihydrofolate reductase and is eliminated by a hydrogen-ion-dependent mechanism in the kidney. We present evidence that omeprazole inhibits methotrexate clearance and may result in potentially toxic methotrexate levels.