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Bryostatin 1 induces productive Epstein-Barr virus replication in latently infected cells: implications for use in
J P Stewart1, A T McGown, J Prendiville
1CRC Department of Molecular Biology, Paterson Institute for Cancer Research, Christie CRC Cancer Centre, Manchester, UK.
Cancer Chemotherapy and Pharmacology
|January 1, 1993
Abstract:
Bryostatin 1 is a novel anti-tumor agent currently undergoing clinical trial. We investigated the effect of this drug on B-lymphocyte cell lines that carry the Epstein-Barr virus and found that it induces these latently infected cells into the production of transforming virus particles over a wide range of concentrations. These results may have clinical implications, particularly with regard to the use of the drug in the immunocompromised patient.