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Correlation between colon adenoma and cancer
1Department of Surgery, National Institute of Oncology, Budapest, Hungary.
Summary
Colon polyps, primarily adenomas, were removed in 9.76% of patients. Malignant transformation was observed in 14.46% of adenomas, supporting the adenoma-to-cancer sequence in colorectal cancer development.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Colorectal Surgery
Background:
- Colorectal polyps are common findings during colonoscopies.
- Adenomas represent a significant precursor to colorectal cancer.
- Understanding polyp characteristics and malignant potential is crucial for patient management.
Purpose of the Study:
- To analyze the incidence and histological findings of polyps removed during colonoscopies.
- To investigate the rate of malignant transformation in colorectal adenomas.
- To evaluate indications for surgical intervention in managing colon polyps.
Main Methods:
- Retrospective analysis of 1301 colonoscopies.
- Histopathological examination of 177 removed polyps.
- Correlation of polyp findings with patient tumor status and surgical history.
Main Results:
- 177 polyps were removed from 127 patients (9.76%).
- 159 polyps (89.83%) were adenomas, with 23 (14.46%) showing malignant transformation.
- Higher polyp prevalence and malignant transformation rates were noted in patients with tumors or prior tumor resection.
Conclusions:
- Findings support the adenoma-to-cancer progression theory.
- Specific criteria for surgical management of colon polyps are proposed, including unremovable polyps, invasive adenocarcinoma, post-polypectomy complications, and technical challenges.
- Timely surgical intervention is essential for complex polyp cases.