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Updated: Jul 28, 2026

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development
Published on: July 13, 2014
Pharmacological aspects of gonadal alcohol and aldehyde-dehydrogenase
1Department of Pharmacology and Toxicology, University of North Dakota School of Medicine, Grand Forks 58202-9037.
Abstract:
1. A brief overview of gonadal alcohol dehydrogenase (ADH) and aldehyde-dehydrogenase (ALDH) is presented and their relationships to gonadal toxicity of ethanol has been discussed. 2. The distributions of ADH and ALDH among major reproductive tissues of rodents, their subcellular localization and kinetic properties were summarized. 3. The sensitivity of testicular ADH and ALDH to ethanol intake, various psychoactive agents and steroidal compounds was assessed and the implication of these enzymes in gonadal ethanol-drug interaction has been suggested. 4. The possible role of testicular ALDH in tumorigenesis and in high altitude endocrine sensitivity to ethanol has been addressed.
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