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Tylophora compounds as Na+/K(+)-ATPase inhibitors
J N Gnabre1, J L Pinnas, R B Bates
1Health Sciences Center, University of Arizona, Tucson, AZ 85724.
General Pharmacology
|September 1, 1993
Abstract:
1. Acetyltylophoroside (AcT) and tylogenin inhibit Na+/K(+)-ATPase in spite of having structures very different from cardiac glycosides (CGs). 2. Calculation of the lowest energy conformations of AcT and tylogenin and superpositions of these with the X-ray conformations of CGs and chlormadinone acetate led to a model for the interaction of these different types of Na+/K(+)-ATPase inhibitors with the receptor.