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Related Experiment Videos

[Sympathetic skin response--physiologic principles, normal values and clinical use]

C Dettmers1, H Faust, D Fatepour

  • 1Neurologische Universitätsklinik, Bonn.

Fortschritte Der Neurologie-Psychiatrie
|November 1, 1993
PubMed
Summary

Sympathetic skin reflex (SSR) testing is reliable for assessing sympathetic sudomotor function in groups. While not age or sex-dependent in healthy individuals, SSR abnormalities are common in polyneuropathy patients.

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Area of Science:

  • Neuroscience
  • Autonomic Nervous System Physiology
  • Clinical Electrophysiology

Context:

  • The sympathetic skin reflex (SSR) is a key indicator of sympathetic sudomotor function.
  • Evaluating SSR in diverse populations is crucial for understanding autonomic nervous system health.
  • Previous research has explored SSR in various neurological conditions, but comprehensive analysis in polyneuropathy is ongoing.

Purpose:

  • To evaluate the sympathetic skin reflex (SSR) in the lower extremities of healthy volunteers and patients with polyneuropathy.
  • To determine the reliability and influencing factors of SSR measurements.
  • To assess the diagnostic utility of SSR in polyneuropathy and compare it with existing literature.

Summary:

  • SSR was successfully elicited in all 60 healthy volunteers, showing consistent biphasic waves with a mean latency of 2.16s, unaffected by age or sex, but weakly correlated with height.

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  • In 39 polyneuropathy patients, 51% exhibited pathological SSR, irrespective of etiology, lesion type, or clinical symptoms.
  • SSR is a viable method for evaluating sympathetic sudomotor function and detecting group differences, though its correlation with individual autonomic disturbances is limited.

    • Impact:

    • This study validates SSR as a reliable electrophysiological tool for assessing sympathetic sudomotor function, particularly for group comparisons.
    • Findings highlight the high prevalence of SSR abnormalities in polyneuropathy, suggesting its potential as a biomarker for autonomic dysfunction in this patient group.
    • The research contributes to the understanding of SSR's applicability in diagnosing and monitoring various neurological and autonomic disorders.