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Epidermodysplasia verruciformis in Africans
1Department of Dermatology, University of Pretoria, Republic of South Africa.
International Journal of Dermatology
|November 1, 1993
Summary
Epidermodysplasia verruciformis (EV) is a rare skin condition caused by human papillomaviruses (HPV). Studies in Africans show EV is typically benign, with a specific HPV type found in all lesion types.
Area of Science:
- Dermatology
- Virology
- Genetics
Background:
- Epidermodysplasia verruciformis (EV) is a rare disorder characterized by persistent human papillomavirus (HPV) infections.
- While EV lacks racial or geographic preference, reports on its occurrence in Africans are scarce.
Purpose of the Study:
- To investigate the clinical presentation and virology of Epidermodysplasia verruciformis (EV) in African patients.
- To address the scarcity of literature on EV in African populations.
Main Methods:
- A study of twenty African patients with EV.
- Literature review on EV occurrence in Africans.
- Virologic studies on ten EV patients.
Main Results:
- Observed lesions included flat warts, pityriasis versicolor-like macules, and seborrheic keratosis-like changes.
- Malignant transformation was rare (one patient).
- An HPV-5-related type was identified in all lesion types across South African patients.
Conclusions:
- Confirmed the generally benign nature of EV in dark-skinned Africans.
- Isolated four HPV types, with a specific HPV-5-related type prevalent in all lesions and patients studied.
- Noted frequent seborrheic keratosis-like changes in African patients with EV.