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Fractionated high-dose rate brachytherapy for intracranial gliomas
1Department of Radiology, Baylor College of Medicine, Houston, TX 77030.
Purpose:
To develop a catheter system for fractionated high-dose rate (HDR) brachytherapy for intracranial gliomas.
Methods And Materials:
The catheter system for stereotactic placement as well as delivery of the high-dose rate iridium-192 source wire is described. The force of the impulse wave from the source wire entering brain equivalent material was measured. Dose volume histograms for the first 5 patients treated are presented.
Results:
The catheter system was found to be satisfactory. The maximum force of the impulse wave was less than 1 acceleration of gravity (which is safe). The patients tolerated the treatment well with no significant problems related to the catheters being left in situ for up to 14 days.
Conclusion:
Based on this pilot experience a phase I dose escalating and morbidity study has been initiated.