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Colchicine in diabetes mellitus
1Department of Medicine, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad.
The Journal of the Association of Physicians of India
|April 1, 1993
Summary
Colchicine, an anti-inflammatory drug, significantly lowered blood glucose in patients with non-insulin dependent diabetes mellitus. This study suggests colchicine possesses anti-diabetic properties with no observed side-effects.
Area of Science:
- Pharmacology
- Endocrinology
- Metabolic Diseases
Background:
- Anti-inflammatory drugs like acetylsalicylic acid can improve insulin response.
- Non-insulin dependent diabetes mellitus (NIDDM) is a metabolic disorder characterized by impaired glucose regulation.
Purpose of the Study:
- To investigate the potential anti-diabetic effects of colchicine in NIDDM patients.
- To evaluate colchicine's impact on blood glucose levels and assess for side-effects.
Main Methods:
- A study was conducted involving NIDDM patients.
- Colchicine was administered at a dose of 0.5 mg three times daily.
- Fasting and post-prandial blood glucose levels were monitored.
Main Results:
- Colchicine significantly reduced both fasting and post-prandial blood glucose levels.
- No adverse side-effects were reported during the colchicine therapy.
- The drug demonstrated a notable impact on glucose control in NIDDM.
Conclusions:
- Colchicine exhibits significant anti-diabetic properties.
- The use of colchicine in NIDDM patients appears safe and effective for glucose management.
- Further research into colchicine's anti-diabetic mechanisms is warranted.