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Transdermal clonidine for ameliorating tamoxifen-induced hot flashes
R M Goldberg1, C L Loprinzi, J R O'Fallon
1Geisinger Clinical Oncology Program, Danville, PA.
Purpose:
To determine the efficacy of transdermal clonidine for alleviating tamoxifen-induced hot flashes in women with a history of breast cancer.
Patients And Methods:
A randomized, double-blind, crossover design was used in this prospective study. Women with a history of breast cancer who were receiving tamoxifen and suffering from hot flashes were potentially eligible for this protocol study.
Results:
Clonidine did reduce hot-flash frequency to a degree that was statistically impressive (P < .0001), but clinically moderate (20% reduction from baseline). It also decreased hot-flash severity (P = .02, 10% reduction from baseline). Clonidine was related to increased mouth dryness (P < .001), constipation (P < .02), itchiness under the patch (P < .01), and drowsiness (P < .05).
Conclusion:
Better means are needed to alleviate hot flashes among patients in whom estrogen therapy is contraindicated.
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