Response of aged neurons to super-hypotonic environment
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Fluorescence and Bioluminescence Imaging of Subcellular Ca2+ in Aged Hippocampal Neurons
Published on: December 1, 2015
1Department of Physiology, Yokohama City University, School of Medicine, Japan.
The Japanese Journal of Physiology
|January 1, 1993
Abstract:
Cultured sensory neurons from aged mice (24 months old) lost capability of cell volume auto-regulatory mechanism after the rapid treatment with a hypotonic solution of 1/4 the normal osmolarity or lower. However, they could survive and extend neurites in super-hypotonic media such as 1/4 osmolar and even 1/8 osmolar culture media when the osmolarity was reduced gradually to such a low level.
