Related Experiment Videos
Isolated bone marrow non-Hodgkin's lymphoma: a clinicopathologic study
Background:
Isolated bone marrow non-Hodgkin's lymphoma (NHL) is rare, and determining the diagnosis is difficult.
Patients:
We describe four patients with apparent isolated bone marrow NHL. The features they had in common included fever, abnormal liver function, pancytopenia, polyserositis, neurologic symptoms, opportunistic infections, and a short, fatal course.
Findings:
Routine cytologic and histologic studies showed intermediate and large lymphomatous cells in the bone marrow, with a predominantly interstitial pattern. Immunophenotyping revealed three cases of T-cell and one case of B-cell NHL. Cytogenetic analysis demonstrated an abnormal clone in two patients.
Conclusion:
The diagnosis of isolated bone marrow NHL should be based on the examination of both bone marrow aspirates and biopsy specimens.