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Isolated bone marrow non-Hodgkin's lymphoma: a clinicopathologic study
Mayo Clinic Proceedings
|January 1, 1994
Summary
Isolated bone marrow non-Hodgkin's lymphoma (NHL) is a rare condition that presents with challenging diagnostic features. Comprehensive bone marrow examination is crucial for accurate diagnosis of this aggressive lymphoma.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Non-Hodgkin's lymphoma (NHL) rarely presents as isolated bone marrow involvement.
- Diagnosis is often challenging due to the rarity and non-specific symptoms.
Observation:
- Four patients presented with apparent isolated bone marrow NHL.
- Common features included fever, abnormal liver function, pancytopenia, polyserositis, neurologic symptoms, and opportunistic infections.
Findings:
- Bone marrow cytology and histology revealed intermediate and large lymphomatous cells with an interstitial pattern.
- Immunophenotyping identified three T-cell and one B-cell NHL.
- Cytogenetic analysis showed an abnormal clone in two patients.
Implications:
- Accurate diagnosis of isolated bone marrow NHL requires examination of both aspirates and biopsy specimens.
- This rare lymphoma subtype follows a rapid and fatal clinical course.
- Understanding the immunophenotypic and cytogenetic characteristics aids in diagnosis and management.