Severe exfoliative dermatitis associated with hand ischemia during cisplatin therapy
Related Experiment Video
Updated: Sep 11, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
Background:
Platinum is one of the most widely used agents in clinical oncology today. Serious toxic effects are well recognized.
Findings:
To our knowledge, the current report describes the first case of severe allergic exfoliative dermatitis associated with ischemia and necrosis of the hands in a patient who had received multiple doses of this agent. We postulate that the tissue damage was caused by vasospasm of small vessels from the initial injury triggered by platinum or its associated immune complexes.
Conclusion:
Platinum has become an integral part of combination chemotherapy for various solid tumors. Clinicians must recognize its toxic side effects and control them within tolerable limits.
Related Concept Videos
Burn Injuries
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Peripheral Artery Disease I: Introduction
Peripheral Artery Disease IV: Nursing Management
Chronic Kidney Disease II: Clinical Manifestations
Healing II: Complications
Diabetic Foot Ulcer

