A neural shift theory of migraine

Migraine headache may lend itself to epidemiological inquiry that includes disruptive serotonergic psychosocial behaviors. To advance our knowledge of the etiology of this neurologic disorder, measurable psychosocial behaviors that are correlated with variability in monoamine neurotransmission need to be examined in the migraine population in a controlled fashion. It may be that those with migraine have a more difficult time adapting to internal or external environmental changes based on a different distribution of serotonin levels or activity. Psychosocial behaviors are outlined as possible serotonin indicator variables for future migraine investigation.