Long-term corneal involvement following drug-induced toxic epidermal necrolysis (Lyell's disease)

Toxic epidermal necrolysis is a mucocutaneous disease that also causes important ocular sequelae. Conjunctival retraction, scars and sicca syndrome with severe corneal lesions are the principal ocular complications, sometimes resulting in a major handicap for the patient. We report a case where long-term sequelae ended in corneal perforation requiring a keratoplasty more than 20 years after the initial attack.