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Evolution of angioid streaks
A M Mansour1, N H Ansari, J A Shields
1University of Texas Medical Branch, Galveston 77555-0787.
Summary
Angioid streaks of the fundus are not present at birth but develop over time. This study reveals their progressive evolution from early hypopigmented streaks to severe vision-threatening conditions.
Area of Science:
- Ophthalmology
- Retinal Degenerative Diseases
Background:
- Angioid streaks are a pathological finding in the fundus.
- Understanding the natural history of angioid streaks is crucial for patient management.
Observation:
- Retrospective analysis of fundus images from 111 subjects with angioid streaks.
- Earliest signs observed at age 8 as narrow, radial, discontinuous hypopigmented streaks.
- Progressive enlargement in length and width of streaks over time.
Findings:
- Angioid streaks evolve dynamically, not being congenital.
- Progression leads to end-stage complications like macular degeneration and choroidal sclerosis.
- The process indicates an underlying retinochoroidal degenerative condition.
Implications:
- Highlights the progressive nature of angioid streaks.
- Suggests the need for long-term monitoring of affected individuals.
- Provides insights into the pathogenesis of retinochoroidal degeneration.