Sisomicin versus netilmicin: in vitro susceptibility testing

Area of Science:

• Microbiology
• Infectious Diseases
• Pharmacology

Background:

• Clinical isolates pose a significant challenge in healthcare settings.
• Emerging antibiotic resistance necessitates the evaluation of existing and novel antimicrobial agents.
• Aminoglycosides are crucial in treating various bacterial infections.

Purpose of the Study:

• To assess the antimicrobial susceptibility of clinical isolates to sisomicin and netilmicin.
• To compare the efficacy of sisomicin and netilmicin against a panel of clinical bacterial strains.
• To determine the activity of netilmicin against multi-drug resistant isolates.

Main Methods:

• Broth microdilution method was employed for susceptibility testing.
• 164 clinical isolates were analyzed.
• Antimicrobial activity was evaluated for sisomicin and netilmicin.

Main Results:

• Sisomicin exhibited activity against 86.1% of the isolates.
• Netilmicin demonstrated activity against 96.4% of the isolates.
• Netilmicin was effective against 93.7% of strains resistant to gentamicin, kanamycin, tobramycin, and sisomicin.

Conclusions:

• Netilmicin displays broad-spectrum activity against clinical isolates.
• Netilmicin is a promising agent for treating infections caused by multi-drug resistant bacteria.
• Sisomicin also shows significant antimicrobial activity, though less potent than netilmicin.