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[Labile arterial hypertension and sympathetic tonus. Hemodynamic study]
Archives Des Maladies Du Coeur Et Des Vaisseaux
|December 1, 1976
Summary
Borderline hypertensive patients exhibit elevated cardiac output and blood volume ratios, linked to increased sympathetic nervous system activity. This suggests sympathetic overactivity is key in raising cardiac output in these individuals.
Area of Science:
- Cardiology
- Physiology
- Hypertension Research
Context:
- Investigating hemodynamic and biochemical factors in borderline hypertension.
- Comparing borderline hypertensive patients with normal subjects.
Purpose:
- To determine cardiac output, blood volumes, vascular reactivity, and dopamine B hydroxylase levels in borderline hypertensives.
- To explore the relationship between these parameters and sympathetic activity.
Summary:
- Cardiac output and the cardiopulmonary (CPBV) to total (TBV) blood volume ratio were significantly higher in borderline hypertensives.
- This ratio correlated directly with pressor response to norepinephrine and dopamine B hydroxylase (DBH) levels.
- Findings indicate sympathetic overactivity significantly contributes to elevated cardiac output in borderline hypertension.
Impact:
- Provides insight into the pathophysiology of borderline hypertension.
- Highlights the role of sympathetic nervous system overactivity.
- Suggests potential targets for managing elevated cardiac output in this population.