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Initiation of phospholipase A2 activity in human platelets by the calcium ion ionophore A23187
Biochimica Et Biophysica Acta
|January 18, 1976
Abstract:
Phospholipase A2 activity in a suspension of intact platelets was induced by addition of a Ca2+-ionophore, A23187. This action of ionophore A23187 was enhanced by EGTA and inhibited by an excess of Ca2+ in the medium, findings which suggest that A23187 is able to mobilize intracellular Ca2+ for the latter's role as an essential cofactor for phospholipase A2 activity.