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Transfusion and second malignancy
C D Ford1, J W Gillette, D L Handrahan
1Tumor Registry, LDS Hospital, Salt Lake City, Utah.
Background:
Perioperative blood transfusion has been reported to cause a variety of immunosuppressive effects, including increased rates of malignancy recurrence. The effect of perioperative transfusion on second malignancy risk has not previously been investigated.
Study Design And Methods:
Second malignancy risk was evaluated in 1053 patients previously operated upon for colon cancer, and these findings are related to perioperative transfusion history.
Results:
Transfusion history did not relate to the probability of a patient's remaining free of second malignancy.
Conclusion:
An increased risk of total or second malignancies (with the possible exception of lung cancer) was not associated with transfusion.