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Prevalence of multiple antibiotic resistance in Neisseria gonorrhoeae
Abstract:
The susceptibility of 100 strains of Neisseria gonorrhoeae to five antimicrobial agents (penicillin, streptomycin, oxytetracycline, sulphamethoxazole, and gentamicin) was examined. Three strains were resistant to each antimicrobial, fourteen exhibited resistance to three or four of the five compounds tested, and 49 were resistant to a single agent, or to pairs of the selected agents. 34 strains were found to be fully sensitive to all of the compounds tested. It is suggested that resistance to gentamicin and sulphamethoxazole may be determined by a multiple resistance gene. The overall frequency of penicillin resistance was found to be 26-5 per cent (MIC greater than 0-06 mug/ml.), suggesting a significant decrease in resistance since 1968.
Insights
This study tested 100 Neisseria gonorrhoeae strains against five antibiotics. While many strains showed resistance, a significant decrease in penicillin resistance was observed compared to 1968.
Area of Science:
- Microbiology
- Antimicrobial Resistance
- Infectious Diseases
Background:
- Neisseria gonorrhoeae is a significant cause of sexually transmitted infections.
- Antimicrobial resistance in N. gonorrhoeae poses a global public health threat.
- Monitoring antibiotic susceptibility is crucial for effective treatment strategies.
Purpose of the Study:
- To determine the antimicrobial susceptibility patterns of 100 Neisseria gonorrhoeae strains.
- To assess the prevalence of resistance to penicillin, streptomycin, oxytetracycline, sulphamethoxazole, and gentamicin.
- To identify potential trends in antibiotic resistance, particularly for penicillin.
Main Methods:
- Susceptibility testing of 100 N. gonorrhoeae isolates against five key antimicrobial agents.
- Quantification of resistance levels, including minimum inhibitory concentrations (MICs).
- Comparative analysis of current resistance frequencies with historical data (1968).
Main Results:
- 34% of strains were fully susceptible to all tested agents.
- 49% exhibited resistance to one or two agents.
- 26.5% of strains showed penicillin resistance (MIC > 0.06 µg/ml), a decrease since 1968.
Conclusions:
- A notable decrease in penicillin resistance among N. gonorrhoeae strains was observed.
- Resistance to gentamicin and sulphamethoxazole may be linked to a multiple resistance gene.
- Continued surveillance of antimicrobial susceptibility is essential for gonorrhea treatment.