Jove
Visualize
Contact Us

Related Experiment Videos

Equine fasting hyperbilirubinemia

L R Engelking1

  • 1Department of Medicine, Tufts University School of Veterinary Medicine, North Grafton, Massachusetts 01536.

Advances in Veterinary Science and Comparative Medicine
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physiology of the endocrine pancreas.

Seminars in veterinary medicine and surgery (small animal)·2000
Same author

Biochemical and physiological manifestations of acute insulin withdrawal.

Seminars in veterinary medicine and surgery (small animal)·2000
Same author

Humic acid-induced echinocyte transformation in human erythrocytes: characterization of morphological changes and determination of the mechanism underlying damage.

Journal of toxicology and environmental health. Part A·2000
Same author

Effects of halothane and methoxyflurane on the hypothalamic-pituitary-adrenal axis in rat.

Brain research bulletin·1998
Same author

Effects of halothane and methoxyflurane on regional brain and spinal cord substance P-like and beta-endorphin-like immunoreactivities in the rat.

Brain research bulletin·1998
Same author

Alterations in catecholamine turnover in specific regions of the rat brain following acute exposure to nitrous oxide.

Brain research bulletin·1998
Same journal

Index.

Advances in veterinary science and comparative medicine·2020
Same journal

Thyroiditis--a model canine autoimmune disease.

Advances in veterinary science and comparative medicine·1995
Same journal

Estimating disease prevalence with health surveys and genetic screening.

Advances in veterinary science and comparative medicine·1995
Same journal

Benefits and burdens: legal and ethical issues raised by veterinary specialization.

Advances in veterinary science and comparative medicine·1995
Same journal

Standards for veterinary clinical trials.

Advances in veterinary science and comparative medicine·1995
Same journal

Veterinary medical specialization.

Advances in veterinary science and comparative medicine·1995
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Fasting hyperbilirubinemia in horses may involve decreased hepatic uptake and potential substrate depletion for conjugation enzymes. Refeeding rapidly reverses this condition, suggesting feeding plays a key role.

Area of Science:

  • Veterinary Medicine
  • Animal Physiology
  • Biochemistry

Background:

  • Fasting hyperbilirubinemia is observed in various mammals, but the exact mechanisms differ across species.
  • In horses, increased bilirubin production is unlikely; instead, reduced hepatic uptake of bilirubin is a suspected factor.

Purpose of the Study:

  • To investigate the underlying mechanisms of fasting hyperbilirubinemia in horses.
  • To explore the role of hepatic uptake, conjugation, and excretion in this physiological phenomenon.

Main Methods:

  • The study reviews existing literature on equine fasting hyperbilirubinemia, considering factors like hepatic blood flow, carrier-mediated uptake, and intracellular transport.
  • It examines the potential impact of hyperlipidemia and competition with free fatty acids.

Related Experiment Videos

  • It also considers the role of UDP-glucuronosyltransferase (UGT) activity and substrate availability for bilirubin conjugation.

    • Main Results:

    • Hepatic uptake of bilirubin appears reduced in fasting horses, more so than compounds with higher hepatic clearance.
    • While competition with free fatty acids is plausible due to hyperlipidemia, it's not fully supported as the sole cause.
    • Intraduodenal glucose administration effectively reduces hyperbilirubinemia and increases biliary bilirubin excretion, suggesting substrate depletion for conjugation.

    Conclusions:

    • Fasting hyperbilirubinemia in horses likely involves impaired hepatic uptake and potentially reduced substrate availability for bilirubin conjugation.
    • Further research is needed to elucidate the precise mechanisms and the impact of feeding on reversing this condition.