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Related Experiment Videos

Establishing a histologic basis for false-negative mammograms

A B Hollingsworth1, L D Taylor, D C Rhodes

  • 1Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City 73190.

American Journal of Surgery
|December 1, 1993
PubMed
Summary

Diffuse histology in breast cancer is a key reason for false-negative mammograms. This infiltrative pattern, particularly in invasive lobular carcinoma, challenges mammography

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Area of Science:

  • Radiology
  • Oncology
  • Pathology

Background:

  • Mammography is a primary screening tool for breast cancer.
  • False-negative mammograms can delay diagnosis and treatment.
  • Understanding reasons for false negatives is crucial for improving diagnostic accuracy.

Purpose of the Study:

  • To investigate the histological characteristics of breast cancers that resulted in false-negative mammograms.
  • To identify specific tumor patterns contributing to mammographic screening failures.

Main Methods:

  • Retrospective review of 264 breast cancer patients.
  • Identification of 100 patients with palpable cancers imaged within 6 months of biopsy.
  • Histological analysis of six cases initially read as negative mammograms.

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Main Results:

  • Five of six false-negative cases exhibited a diffusely infiltrative histological pattern.
  • These included invasive lobular carcinomas and multifocal invasive ductal carcinomas.
  • Severe mammographic breast density was not a consistent factor in these false-negative cases.

Conclusions:

  • Diffuse histological patterns are a significant cause of false-negative mammograms.
  • The reliance of mammography on anatomic contrast limits its ability to detect infiltrative cancers.
  • Improved adjunct imaging techniques are needed to overcome limitations of mammography for detecting diffuse breast cancers.