Related Experiment Video

Updated: Aug 11, 2026

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
09:39

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages

Published on: May 30, 2013

[Cholera in children. A report of 8 cases]

L A Lezama-Basulto1, F Mota-Hernández, E Bravo-Barrios

  • 1Servicio de Hidratación Oral, Hospital Infantil de México Federico Gómez, D.F.

Boletin Medico Del Hospital Infantil De Mexico
|November 1, 1993
PubMed

Insights

Pediatric cholera, caused by Vibrio cholerae 01, can lead to severe dehydration and hypovolemic shock. Early intravenous rehydration followed by oral therapy proved effective in treating eight young children, with most recovering fully within five days.

Area of Science:

  • Infectious Diseases
  • Pediatrics
  • Gastroenterology

Background:

  • Cholera, an acute intestinal infection by Vibrio cholerae 01, poses a significant risk of severe dehydration and hypovolemic shock if untreated.
  • Limited data exists on cholera's impact and management specifically within pediatric populations.

Observation:

  • This case series details eight pediatric cholera patients aged 17 months to 4 years.
  • Seven of the eight children presented with dehydration, including three with critical hypovolemic shock.
  • Management involved intravenous rehydration for shock cases, followed by oral rehydration therapy.

Findings:

  • Six patients experienced uneventful recovery within five days.
  • One patient developed abdominal distention, possibly linked to hypopotassemia.
  • Another patient presented with hyponatremia, leading to seizures.

Implications:

  • Intravenous and oral rehydration therapy is effective for pediatric cholera, even in severe cases.
  • Monitoring for electrolyte imbalances like hypopotassemia and hyponatremia is crucial in pediatric cholera management.
  • This study highlights the importance of prompt and appropriate treatment for severe dehydration in children with cholera.

More Related Videos

Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates07:58

Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates

Published on: May 30, 2017

Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model08:03

Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model

Published on: July 12, 2018

Related Concept Videos

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
Botulism01:22

Botulism

Botulism is a life-threatening neuroparalytic condition caused by botulinum neurotoxin, which is produced by the bacterium Clostridium botulinum, a Gram-positive, spore-forming, obligate anaerobe.In adults, the toxin enters the body in different ways: in foodborne botulism, the preformed toxin is absorbed in the intestine. In wound botulism, spores grow in injured tissue and release the toxin into the blood. Infant botulism differs mechanistically from adult forms. In infants, botulism commonly...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
Pyloric Obstruction01:11

Pyloric Obstruction

Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...