[Hodgkin's disease with the nephrotic syndrome. A case report]
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E López-Aguilar1, P González-Chirinos, J Fernández-Diez
1Servicio de Oncología y Nefrología, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, D.F., México.
Insights
This study reports a pediatric case of Hodgkin's disease presenting with nephrotic syndrome. Treatment of the cancer led to remission of the kidney condition, suggesting a link between the two.
Area of Science:
- Pediatric Oncology
- Nephrology
- Immunology
Background:
- Hodgkin's disease is a cancer of the lymphatic system.
- Nephrotic syndrome is a kidney disorder characterized by protein in the urine.
Observation:
- A nine-year-old boy was diagnosed with Hodgkin's disease and nephrotic syndrome.
- Renal biopsy revealed minimal change disease, a common cause of nephrotic syndrome in children.
Findings:
- The patient achieved remission of nephrotic syndrome concurrently with the control of Hodgkin's disease.
- Immunologic studies of renal tissues did not reveal a clear mechanism linking neoplastic cells to glomerular damage.
Implications:
- This case highlights a potential association between Hodgkin's disease and nephrotic syndrome in pediatric patients.
- Further research is needed to elucidate the underlying pathophysiology of this association.
Abstract:
It is presented a child with Hodgkin's disease which at diagnosis present associated at nephrotic syndrome. Male of nine years old which present a ganglionic growing of left jugular chain of one year evolution without systemic symptoms and anasarca. Were underwent a ganglionic biopsy with histopathology report of Hodgkin's disease mixed cellular variety and renal biopsy with histopathology report of minimal change disease. The patient present remission of nephrotic syndrome in simultaneous form at the control of the disease. In the reported cases of nephrotic syndrome associated with Hodgkin's disease it not clear the physiopathology. In this patient were realized immunologic studies of renal tissues to treat to find a possible mechanism of action of the neoplastic cells on the basal glomerular membrane but we can not found.