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Support for the shape concept of lipid structure based on a headgroup volume approach
Y C Lee1, T F Taraschi, N Janes
1Department of Pathology and Cell Biology, Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Biophysical Journal
|October 1, 1993
Abstract:
Headgroup volumes of seven dioleoyl lipid species, calculated from covalent radii, are shown to correlate linearly (r = 0.95) with the ability of those lipids to alter the midpoint temperature of the lamellar to inverted hexagonal phase transition (L alpha-->HII) of a 95 mole fraction percent phosphatidylethanolamine matrix. The results illustrate the utility of the shape concept and basic considerations of headgroup volume as a predictive tool for the determination of lipid structure.