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Related Experiment Videos

Photoreceptors regulating circadian behavior: a mouse model

R G Foster1, S Argamaso, S Coleman

  • 1Department of Biology, University of Virginia, Charlottesville 22901.

Journal of Biological Rhythms
|January 1, 1993
PubMed
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Circadian light responses persist in mice with hereditary retinal disorders. This suggests a distinct photoreceptor system, independent of vision, mediates these crucial biological rhythms.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Chronobiology

Background:

  • Hereditary retinal disorders cause vision loss but may not affect circadian rhythms.
  • The suprachiasmatic nucleus (SCN) is central to the circadian entrainment pathway.
  • Understanding the photoreceptors for circadian light detection is crucial.

Purpose of the Study:

  • To investigate circadian photoreception in mice with hereditary retinal disorders (rd/rd and rds/rds).
  • To identify the photopigment responsible for mediating circadian responses to light.
  • To determine if known opsins are exclusively involved in circadian photoreception.

Main Methods:

  • Assessed circadian responses to light in rd/rd and rds/rds mice.
  • Measured c-fos expression in the SCN as a marker of neural activation.

Related Experiment Videos

  • Performed action spectrum studies and high-pressure liquid chromatography for photopigment analysis.
  • Quantified opsin messenger RNA levels in retinally degenerate mice.

    • Main Results:

    • Circadian responses to light were unaffected in mice with hereditary retinal disorders.
    • Identical levels of Fos expression were observed in the SCN of rd/rd and wild-type mice upon light exposure.
    • Evidence suggests the photopigment involves an opsin and 11-cis-retinaldehyde.
    • No single opsin type (rod, blue cone, green-red cone) was exclusively responsible for circadian light responses.

    Conclusions:

    • Circadian photoreception is maintained in the absence of functional vision.
    • A small number of photoreceptor cells, potentially without outer segments, may mediate these responses.
    • An unrecognized class of photoreceptive cell in the mammalian retina could be involved in circadian entrainment.