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Fluconazole-induced toxic epidermal necrolysis in a patient with human immunodeficiency virus infection
A Azón-Masoliver1, J Vilaplana
1Department of Dermatology, Hospital de Sant Joan, Reus, Spain.
Abstract:
Patients with human immunodeficiency virus (HIV) infection are prone to severe drug reactions, mainly from sulfonamides. We report the case of a 33-year-old male patient with HIV infection (group IV C-2 of CDC staging system) that developed a toxic epidermal necrolysis (TEN) affecting more than 70% of the body surface area and severe mucosal involvement after starting fluconazole for a recurrent oral thrush with dysphagia. This is to our knowledge the first reported case of TEN due to fluconazole.
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